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HDGF2

Official Full Name
HDGF like 2
Organism
Homo sapiens
GeneID
84717
Background
This gene encodes a member of the hepatoma-derived growth factor (HDGF) family. The protein includes an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. The protein functions in LEDGF/p75-independent HIV-1 replication by determining HIV-1 integration site selection. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Synonyms
HDGFL2; HRP2; HDGF2; HRP-2; HDGF-2; HDGFRP2;

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