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GRM7


Official Full Name
glutamate metabotropic receptor 7
Organism
Homo sapiens
Gene ID
2917
Background
L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Synonyms
GLUR7; MGLU7; GPRC1G; MGLUR7; NEDSHBA; PPP1R87

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SHH105779 shRNA set against Mouse Grm7(NM_177328.3) Inquiry
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MiUTR1M-05394 GRM7 miRNA 3'UTR clone Inquiry
MiUTR1R-02304 GRM7 miRNA 3'UTR clone Inquiry
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MiUTR3H-06544 GRM7 miRNA 3'UTR clone Inquiry
CDCB190169 Rabbit GRM7 ORF clone (XM_002720620.2) Inquiry
CDCL114895 Mouse Grm7 ORF clone (NM_177328.3) Inquiry
CDCR324303 Human GRM7 ORF Clone(NM_181874.2) Inquiry
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