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GPX4


Official Full Name
glutathione peroxidase 4
Organism
Homo sapiens
Gene ID
2879
Background
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Transcript variants resulting from alternative splicing or use of alternate promoters have been described to encode isoforms with different subcellular localization. [provided by RefSeq, Dec 2018]
Synonyms
MCSP; SMDS; GPx-4; PHGPx; snGPx; GSHPx-4; snPHGPx

Cat.No. Product Name Price
CSC-RO01371 Mouse Gpx4 Stable Cell Line - RAW 264.7 Inquiry
Cat.No. Product Name Price
SHH307406 shRNA set against Rat GPX4 (NM_017165.2) Inquiry
SHH102503 shRNA set against Mouse Gpx4(NM_001037741.2) Inquiry
SHH102521 shRNA set against Rat Gpx4(NM_017165.2) Inquiry
SHH102539 shRNA set against Rat Gpx4(NM_001039849.1) Inquiry
SHH102593 shRNA set against Mouse Gpx4(NM_008162.2) Inquiry
SHH307402 shRNA set against Mouse GPX4 (NM_008162.2) Inquiry
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CDCL114447 Mouse Gpx4 ORF clone (NM_001037741.2) Inquiry
CDFG018159 Mouse Gpx4 cDNA Clone(NM_001037741.2) Inquiry
CDFL005316 Mouse Gpx4 cDNA Clone(NM_008162.2) Inquiry
CDFR004727 Rat Gpx4 cDNA Clone(NM_001039849.1) Inquiry
CDFR011217 Rat Gpx4 cDNA Clone(NM_017165.2) Inquiry
MiUTR1M-05348 GPX4 miRNA 3'UTR clone Inquiry
MiUTR1M-05349 GPX4 miRNA 3'UTR clone Inquiry
MiUTR1R-02270 GPX4 miRNA 3'UTR clone Inquiry
MiUTR1R-02271 GPX4 miRNA 3'UTR clone Inquiry
CDCL114449 Mouse Gpx4 ORF clone (NM_008162.2) Inquiry
CDCR371771 Rat Gpx4 ORF Clone(NM_001039849.1) Inquiry
CDCR378231 Rat Gpx4 ORF Clone(NM_017165.2) Inquiry
CDCS406989 Human GPX4 ORF Clone (BC011836) Inquiry
CDCS406990 Human GPX4 ORF Clone (BC010157) Inquiry
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CC-590 GPX4 Easy KO Kit Inquiry
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