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GNE


Official Full Name
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Organism
Homo sapiens
Gene ID
10020
Background
The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Synonyms
NM; DMRV; IBM2; Uae1; GLCNE; THC12

Cat.No. Product Name Price
SHH304838 shRNA set against Rat GNE (NM_053765.2) Inquiry
SHH304834 shRNA set against Mouse GNE (NM_015828.3) Inquiry
SHW002023 shRNA set against Chicken GNE (NM_001031432) Inquiry
SHW017016 shRNA set against Danio rerio GNE (NM_200883) Inquiry
Cat.No. Product Name Price
CDFR013513 Rat Gne cDNA Clone(NM_053765.2) Inquiry
MiUTR1R-02176 GNE miRNA 3'UTR clone Inquiry
CDCB163498 Chicken GNE ORF Clone (NM_001031432) Inquiry
CDCB178491 Danio rerio GNE ORF Clone (NM_200883) Inquiry
CDCB193358 Rabbit GNE ORF clone (XM_008266504.1) Inquiry
CDCL113147 Mouse GNE ORF clone (NM_001190383.1) Inquiry
CDCL113149 Mouse GNE ORF clone (NM_001190384.1) Inquiry
CDCL113151 Mouse GNE ORF clone (NM_001190388.1) Inquiry
CDCR243155 Mouse Gne ORF Clone(NM_001190414.1) Inquiry
CDCR349007 Human GNE ORF Clone(NM_001128227.2) Inquiry
CDCR380545 Rat Gne ORF Clone(NM_053765.2) Inquiry
CDCS407844 Human GNE ORF Clone (BC121179) Inquiry
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