Transfected Stable Cell Lines
Reliable | High-Performance | Wide Rage
Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
| Cat.No. | Product Name | Price |
|---|---|---|
| CSC-DC006254 | Panoply™ Human GIF Knockdown Stable Cell Line | Inquiry |
| CSC-DC009520 | Panoply™ Human MIF Knockdown Stable Cell Line | Inquiry |
| CSC-DC009856 | Panoply™ Human MT3 Knockdown Stable Cell Line | Inquiry |
| CSC-SC006254 | Panoply™ Human GIF Over-expressing Stable Cell Line | Inquiry |
| CSC-SC009520 | Panoply™ Human MIF Over-expressing Stable Cell Line | Inquiry |
| CSC-SC009856 | Panoply™ Human MT3 Over-expressing Stable Cell Line | Inquiry |
| CLOE-0409 | Human GIF HEK293 Cell Lysate | Inquiry |
| CLOE-1580 | Human MIF HEK293 Cell Lysate | Inquiry |
| CLOE-2938 | Mouse Mif (His) HEK293 Cell Lysate | Inquiry |
| Cat.No. | Product Name | Price |
|---|---|---|
| AD09959Z | Human MIF adenoviral particles | Inquiry |
| LV13589L | human GIF (NM_005142) lentivirus particles | Inquiry |
| LV18266L | human MIF (NM_002415) lentivirus particles | Inquiry |
| LV18712L | human MT3 (NM_005954) lentivirus particles | Inquiry |
| Cat.No. | Product Name | Price |
|---|---|---|
| SHH084323 | shRNA set against Rat Gif(NM_017162.2) | Inquiry |
| SHH084287 | shRNA set against Mouse Gif(NM_008118.3) | Inquiry |
| SHH084305 | shRNA set against Human GIF(NM_005142.2) | Inquiry |
| SHH190001 | shRNA set against Human MIF(NM_002415.1) | Inquiry |
| SHH190019 | shRNA set against Mouse Mif(NM_010798.2) | Inquiry |
| SHH190037 | shRNA set against Rat Mif(NM_031051.1) | Inquiry |
| SHH301014 | shRNA set against Human GIF (NM_005142.2) | Inquiry |
| SHH301018 | shRNA set against Mouse GIF (NM_008118.3) | Inquiry |
| SHH301022 | shRNA set against Rat GIF (NM_017162.2) | Inquiry |
| SHH346028 | shRNA set against Human MT3 (NM_005954.2) | Inquiry |
| SHH346032 | shRNA set against Mouse MT3 (NM_013603.2) | Inquiry |
| SHH346036 | shRNA set against Rat MT3 (NM_053968.3) | Inquiry |
| SHL089886 | shRNA set against Rat LOC690050(NM_001079531.1) | Inquiry |
| SHW002641 | shRNA set against Chicken MT3 (NM_001097538) | Inquiry |
| SHW009733 | shRNA set against Danio rerio MIF (NM_001043321) | Inquiry |
| Cat.No. | Product Name | Price |
|---|---|---|
| RP00663 | Recombinant Human MIF (C-His) | Inquiry |
| Cat.No. | Product Name | Price |
|---|---|---|
| MiUTR1R-03916 | MIF miRNA 3'UTR clone | Inquiry |
| MiUTR1M-07118 | MIF miRNA 3'UTR clone | Inquiry |
| MiUTR1M-05030 | GIF miRNA 3'UTR clone | Inquiry |
| MiUTR1H-06495 | MT3 miRNA 3'UTR clone | Inquiry |
| MiUTR1H-06307 | MIF miRNA 3'UTR clone | Inquiry |
| MiUTR1H-04032 | GIF miRNA 3'UTR clone | Inquiry |
| CDFR012527 | Rat Mif cDNA Clone(NM_031051.1) | Inquiry |
| CDFR011214 | Rat Gif cDNA Clone(NM_017162.2) | Inquiry |
| CDCR244891 | Mouse Gif ORF Clone(NM_008118.3) | Inquiry |
| CDFH011839 | Human MT3 cDNA Clone(NM_005954.2) | Inquiry |
| CDFH011493 | Human MIF cDNA Clone(NM_002415.1) | Inquiry |
| CDFH007562 | Human GIF cDNA Clone(NM_005142.2) | Inquiry |
| MiUTR1R-02102 | GIF miRNA 3'UTR clone | Inquiry |
| CDCS412494 | Human MT3 ORF Clone (BC013081) | Inquiry |
| CDCS412119 | Human GIF ORF Clone (BC037958) | Inquiry |
| CDCR380677 | Rat Mt3 ORF Clone(NM_053968.3) | Inquiry |
| CDCR379549 | Rat Mif ORF Clone(NM_031051.1) | Inquiry |
| CDCR378228 | Rat Gif ORF Clone(NM_017162.2) | Inquiry |
| CDCR291697 | Human MT3 ORF Clone(NM_005954.2) | Inquiry |
| CDCR289687 | Human GIF ORF Clone(NM_005142.2) | Inquiry |
| CDCR252094 | Mouse Mt3 ORF Clone(NM_013603.2) | Inquiry |
| CDCL185348 | Mouse MIF ORF clone(NM_010798.2) | Inquiry |
| CDCL185347 | Human MIF ORF clone(NM_002415.1) | Inquiry |
| CDCB195539 | Rabbit MT3 ORF clone (NM_001082220.2) | Inquiry |
| CDCB194396 | Rabbit MIF ORF clone (XM_002722561.2) | Inquiry |
| CDCB184217 | Rabbit GIF ORF clone (XM_002709184.2) | Inquiry |
| CDCB171208 | Danio rerio MIF ORF Clone (NM_001043321) | Inquiry |
| CDCB164116 | Chicken MT3 ORF Clone (NM_001097538) | Inquiry |
| CDCS410781 | Human MIF ORF Clone (BC000447) | Inquiry |
| CDCB159897 | Human GIF ORF clone (BC037958) | Inquiry |
Recent Researches
Macrophage migration inhibitory factor (MIF) is a cytokine with multiple biological activities. It is the core of immune regulation and plays an important role in the inflammation and immune response of the body. In some diseases, the expression level of MIF has changed. Two polymorphic loci in its promoter affect its expression and are associated with susceptibility, severity and drug resistance in certain diseases.
The human MIF gene is located on chromosome 21q11.2, and the length of mRNA is about 0.8 kb. The MIF gene encodes 114 amino acids with a relative molecular mass of 12.5 x 103. About 90% of the MIF genes in mammals are homologous to fish, mites, parasites, certain plants, and cyanobacteria. The conservation of the MIF gene between species suggests that MIF proteins may have important biological functions. MIF is widely expressed in many tissues and cells, such as anterior pituitary cells, activated T lymphocytes, mononuclear macrophages, liver, kidney, and spleen.
Four gene polymorphisms have been found in the MIF gene, namely, SNP 173 (rs755622), +254 (rs2096525), +656 (rs2070766) and 1,794 CATT. Microsatellite polymorphisms are present in introns at +254 and +656 loci, as well as in promoters at 1,173 and 1,794 loci. Current studies have confirmed that MIF gene polymorphisms and increased MIF protein concentrations are associated with ulcerative colitis, psoriasis and tuberculosis. These diseases are often accompanied by inflammatory reactions, suggesting a key role of MIF in promoting the development and progression of these diseases.
Up to now, studies have shown that MIF gene mutations or polymorphisms are associated with arthritis, childhood nephropathy syndrome, asthma, autoimmune skin diseases, digestive system diseases (inflammatory bowel disease, gastrointestinal cancer and pancreatitis), prostatitis, and heart ischemia. In short, MIF proteins play an important role in acute and chronic inflammation and autoimmune diseases. Studying the functional polymorphism of its promoter will help to elucidate the mechanism of susceptibility, severity and drug resistance in different populations. Analysis of patients' MIF genotypes can help to categorize at-risk patients and identify which patients can conduct anti-MIF treatment strategies.
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