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GNB3


Official Full Name
G protein subunit beta 3
Organism
Homo sapiens
Gene ID
2784
Background
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]
Synonyms
HG2D; CSNB1H

Cat.No. Product Name Price
SHH092171 shRNA set against Human GNB3(NM_002075.2) Inquiry
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SHH304794 shRNA set against Human GNB3 (NM_002075.2) Inquiry
SHH304798 shRNA set against Mouse GNB3 (NM_013530.1) Inquiry
SHH304802 shRNA set against Rat GNB3 (NM_021858.3) Inquiry
Cat.No. Product Name Price
CDFH007727 Human GNB3 cDNA Clone(NM_002075.2) Inquiry
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CDCB189841 Rabbit GNB3 ORF clone (XM_002712904.2) Inquiry
CDCL113123 Mouse GNB3 ORF clone (NM_002075.2) Inquiry
CDCL113127 Mouse Gnb3 ORF clone (NM_013530.1) Inquiry
CDCR378852 Rat Gnb3 ORF Clone(NM_021858.3) Inquiry
CDCS410597 Human GNB3 ORF Clone (BC015920) Inquiry
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