Pages
Products

FIP1L1


Official Full Name
factor interacting with PAPOLA and CPSF1
Organism
Homo sapiens
Gene ID
81608
Background
This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Synonyms
Rhe; FIP1; hFip1

Cat.No. Product Name Price
SHH295089 shRNA set against Rat FIP1L1 (NM_001008295.1) Inquiry
SHH060113 shRNA set against Rat Fip1l1(NM_001008295.1) Inquiry
SHH295081 shRNA set against Human FIP1L1 (NM_030917.3) Inquiry
SHH295085 shRNA set against Mouse FIP1L1 (NM_024183.5) Inquiry
Cat.No. Product Name Price
MiUTR3H-09386 FIP1L1 miRNA 3'UTR clone Inquiry
MiUTR3H-09384 FIP1L1 miRNA 3'UTR clone Inquiry
MiUTR1R-01914 FIP1L1 miRNA 3'UTR clone Inquiry
CDFR001757 Rat Fip1l1 cDNA Clone(NM_001008295.1) Inquiry
CDFL004681 Mouse Fip1l1 cDNA Clone(NM_024183.5) Inquiry
CDFH006910 Human FIP1L1 cDNA Clone(NM_001134937.1) Inquiry
CDFH006909 Human FIP1L1 cDNA Clone(NM_001134938.1) Inquiry
CDFG019907 Mouse Fip1l1 cDNA Clone(NM_001159574.1) Inquiry
CDFG019905 Mouse Fip1l1 cDNA Clone(NM_001159573.1) Inquiry
MiUTR3H-09385 FIP1L1 miRNA 3'UTR clone Inquiry
CDCS408031 Human FIP1L1 ORF Clone (BC110383) Inquiry
CDCS408029 Human FIP1L1 ORF Clone (BC017724) Inquiry
CDCR368824 Rat Fip1l1 ORF Clone(NM_001008295.1) Inquiry
CDCR256367 Mouse Fip1l1 ORF Clone(NM_024183.5) Inquiry
CDCL108439 Mouse Fip1l1 ORF clone (NM_001159574.1) Inquiry
CDCL108437 Mouse Fip1l1 ORF clone (NM_001159573.1) Inquiry
CDCL108429 Human FIP1L1 ORF clone (NM_001134938.1) Inquiry
CDCL108427 Mouse FIP1L1 ORF clone (NM_001134937.1) Inquiry
CDCS408030 Human FIP1L1 ORF Clone (BC052959) Inquiry
CDCB193001 Rabbit FIP1L1 ORF clone (XM_002721784.2) Inquiry
Quick Inquiry