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F13A1


Official Full Name
coagulation factor XIII A chain
Organism
Homo sapiens
Gene ID
2162
Background
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]
Synonyms
F13A

Cat.No. Product Name Price
SHH043355 shRNA set against Human F13A1(NM_000129.3) Inquiry
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SHH288409 shRNA set against Mouse F13A1 (NM_028784.3) Inquiry
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SHW005194 shRNA set against Chicken F13A1 (NM_204685) Inquiry
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Cat.No. Product Name Price
CDCB171974 Danio rerio F13A1B ORF Clone (NM_001077154) Inquiry
CDCR261844 Mouse F13a1 ORF Clone(NM_028784.3) Inquiry
CDCS405444 Human F13A1 ORF Clone (BC027963) Inquiry
CDFR011745 Rat F13a1 cDNA Clone(NM_021698.2) Inquiry
MiUTR1H-03361 F13A1 miRNA 3'UTR clone Inquiry
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CDCB159022 Human F13A1 ORF clone (BC027963) Inquiry
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