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EIF2S1


Official Full Name
eukaryotic translation initiation factor 2 subunit alpha
Organism
Homo sapiens
Gene ID
1965
Background
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]
Synonyms
EIF2; EIF-2; EIF2A; EIF-2A; EIF-2alpha

Cat.No. Product Name Price
CSC-RT2285 Human EIF2S1 Knockout Cell Line-HEK293T Inquiry
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SHH284373 shRNA set against Mouse EIF2S1 (NM_026114.3) Inquiry
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CDCB194181 Rabbit EIF2S1 ORF clone (XM_002719515.2) Inquiry
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