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DUT


Official Full Name
deoxyuridine triphosphatase
Organism
Homo sapiens
Gene ID
1854
Background
This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]
Synonyms
BMFDMS; dUTPase

Cat.No. Product Name Price
SHW007410 shRNA set against Danio rerio DUT (NM_001006005) Inquiry
SHH019613 shRNA set against Human DUT(NM_001025248.1) Inquiry
SHH019631 shRNA set against Human DUT(NM_001025249.1) Inquiry
SHH019649 shRNA set against Human DUT(NM_001948.3) Inquiry
SHH019667 shRNA set against Rat Dut(NM_001040271.1) Inquiry
SHH019703 shRNA set against Rat Dut(NM_053592.2) Inquiry
SHH281949 shRNA set against Human DUT (NM_001948.3) Inquiry
SHH281953 shRNA set against Mouse DUT (NM_023595.6) Inquiry
SHH281957 shRNA set against Rat DUT (NM_053592.2) Inquiry
SHW002469 shRNA set against Chicken DUT (NM_001079488) Inquiry
Cat.No. Product Name Price
MiUTR1R-01618 DUT miRNA 3'UTR clone Inquiry
MiUTR1H-03047 DUT miRNA 3'UTR clone Inquiry
MiUTR1H-03046 DUT miRNA 3'UTR clone Inquiry
MiUTR1H-03045 DUT miRNA 3'UTR clone Inquiry
CDFR013314 Rat Dut cDNA Clone(NM_053592.2) Inquiry
CDFR004742 Rat Dut cDNA Clone(NM_001040271.1) Inquiry
CDFH005505 Human DUT cDNA Clone(NM_001948.3) Inquiry
CDFH005504 Human DUT cDNA Clone(NM_001025249.1) Inquiry
CDFH005503 Human DUT cDNA Clone(NM_001025248.1) Inquiry
CDFH005502 Human DUT cDNA Clone(NM_001025248.1) Inquiry
MiUTR1R-01617 DUT miRNA 3'UTR clone Inquiry
CDCS406702 Human DUT ORF Clone (BC110377) Inquiry
CDCR380401 Rat Dut ORF Clone(NM_053592.2) Inquiry
CDCR371784 Rat Dut ORF Clone(NM_001040271.1) Inquiry
CDCR342457 Human DUT ORF Clone(NM_001025249.1) Inquiry
CDCR342455 Human DUT ORF Clone(NM_001025248.1) Inquiry
CDCR281974 Human DUT ORF Clone(NM_001948.3) Inquiry
CDCR256160 Mouse Dut ORF Clone(NM_023595.6) Inquiry
CDCR238733 Mouse Dut ORF Clone(NM_001159646.1) Inquiry
CDCB192594 Rabbit DUT ORF clone (XM_008269058.1) Inquiry
CDCB168885 Danio rerio DUT ORF Clone (NM_001006005) Inquiry
CDCS406701 Human DUT ORF Clone (BC033645) Inquiry
CDCB163944 Chicken DUT ORF Clone (NM_001079488) Inquiry
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