Pages
Products

DFFB


Official Full Name
DNA fragmentation factor subunit beta
Organism
Homo sapiens
Gene ID
1677
Background
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined. [provided by RefSeq, Sep 2013]
Synonyms
CAD; CPAN; DFF2; DFF40; DFF-40

Cat.No. Product Name Price
SHH002243 shRNA set against Mouse Dffb(NM_007859.4) Inquiry
SHH002261 shRNA set against Human DFFB(NM_004402.2) Inquiry
SHH002279 shRNA set against Rat Dffb(NM_053362.1) Inquiry
SHH277289 shRNA set against Human DFFB (NM_004402.2) Inquiry
SHH277293 shRNA set against Mouse DFFB (NM_007859.4) Inquiry
SHH277297 shRNA set against Rat DFFB (NM_053362.1) Inquiry
SHW004801 shRNA set against Chicken DFFB (NM_204285) Inquiry
SHW015640 shRNA set against Danio rerio DFFB (NM_194404) Inquiry
Cat.No. Product Name Price
CDCR287798 Human DFFB ORF Clone(NM_004402.2) Inquiry
CDFH005006 Human DFFB cDNA Clone(NM_004402.2) Inquiry
CDFR013116 Rat Dffb cDNA Clone(NM_053362.1) Inquiry
MiUTR1H-02789 DFFB miRNA 3'UTR clone Inquiry
MiUTR1M-03819 DFFB miRNA 3'UTR clone Inquiry
MiUTR1R-01469 DFFB miRNA 3'UTR clone Inquiry
CDCB166276 Chicken DFFB ORF Clone (NM_204285) Inquiry
CDCB177115 Danio rerio DFFB ORF Clone (NM_194404) Inquiry
CDCB187804 Rabbit DFFB ORF clone (XM_008253882.1) Inquiry
CDCH385350 Rat DFFB ORF clone(NM_053362.1) Inquiry
CDCR244435 Mouse Dffb ORF Clone(NM_007859.4) Inquiry
Quick Inquiry