Transfected Stable Cell Lines
Reliable | High-Performance | Wide Rage
Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
| Cat.No. | Product Name | Price |
|---|---|---|
| CSC-DC004129 | Panoply™ Human DDR1 Knockdown Stable Cell Line | Inquiry |
| CSC-SC004129 | Panoply™ Human DDR1 Over-expressing Stable Cell Line | Inquiry |
| CSC-RT2005 | DDR1 Knockout Cell Line-HeLa | Inquiry |
| CLOE-1227 | Human DDR1 HEK293 Cell Lysate | Inquiry |
| CLOE-1228 | Human DDR1 Insect Cell Lysate | Inquiry |
| CLOE-1896 | Rat Ddr1 (His) HEK293 Cell Lysate | Inquiry |
| CLOE-1899 | Rat Ddr1 (Fc) HEK293 Cell Lysate | Inquiry |
| CLOE-2426 | Mouse Ddr1 Insect Cell Lysate | Inquiry |
| CLOE-2431 | Mouse Ddr1 HEK293 Cell Lysate | Inquiry |
| CLOE-2432 | Mouse Ddr1(Fc) HEK293 Cell Lysate | Inquiry |
| CLKO-1865 | DDR1 KO Cell Lysate-HeLa | Inquiry |
| CSC-SC004129-1 | Human DDR1 Stable Cell Line - CHO-K1 | Inquiry |
| CSC-RH0145M | Humanized DDR1 Murine Tumor Cell Line - LL/2 (LLC1) | Inquiry |
| CSC-RH0167M | Humanized DDR1 Murine Tumor Cell Line | Inquiry |
| Cat.No. | Product Name | Price |
|---|---|---|
| AD04683Z | Human DDR1 adenoviral particles | Inquiry |
| LV00258Z | Human DDR1 lentiviral particles | Inquiry |
| Cat.No. | Product Name | Price |
|---|---|---|
| SHG226239 | shRNA set against Human DDR1(NM_013994.2) | Inquiry |
| SHG226221 | shRNA set against Mouse Ddr1(NM_007584.2) | Inquiry |
| SHG226285 | shRNA set against Mouse Ddr1(NM_172962.1) | Inquiry |
| SHG226303 | shRNA set against Human DDR1(NM_001954.4) | Inquiry |
| SHG226321 | shRNA set against Human DDR1(NM_013993.2) | Inquiry |
| SHH275725 | shRNA set against Human DDR1 (NM_001954.4) | Inquiry |
| SHH275729 | shRNA set against Mouse DDR1 (NM_007584.2) | Inquiry |
| SHH275733 | shRNA set against Rat DDR1 (NM_013137.2) | Inquiry |
| Cat.No. | Product Name | Price |
|---|---|---|
| RP00050 | Recombinant Mouse DDR1 (C-6His) | Inquiry |
| RP00065 | Recombinant Mouse DDR1 (C-6His) | Inquiry |
| RP00083 | Recombinant Rhesus Macaque DDR1 (C-6His) | Inquiry |
| RP00095 | Recombinant Human DDR1 (C-6His) | Inquiry |
| RP00109 | Recombinant Mouse DDR1 (C-6His) | Inquiry |
| RP00114 | Recombinant Human DDR1 (C-6His) | Inquiry |
| Cat.No. | Product Name | Price |
|---|---|---|
| CDCB194774 | Rabbit DDR1 ORF clone (XM_008262692.1) | Inquiry |
| MiUTR1H-02717 | DDR1 miRNA 3'UTR clone | Inquiry |
| MiUTR1H-02716 | DDR1 miRNA 3'UTR clone | Inquiry |
| MiUTR1H-02715 | DDR1 miRNA 3'UTR clone | Inquiry |
| CDFR010936 | Rat Ddr1 cDNA Clone(NM_013137.2) | Inquiry |
| CDFL003498 | Mouse Ddr1 cDNA Clone(NM_172962.1) | Inquiry |
| CDFH004889 | Human DDR1 cDNA Clone(NM_013994.2) | Inquiry |
| CDFH004888 | Human DDR1 cDNA Clone(NM_013993.2) | Inquiry |
| CDFH004887 | Human DDR1 cDNA Clone(NM_001954.4) | Inquiry |
| CDFH004886 | Human DDR1 cDNA Clone(NM_001954.4) | Inquiry |
| CDCS409583 | Human DDR1 ORF Clone (BC070070) | Inquiry |
| CDCL183900 | Mouse DDR1 ORF clone(NM_172962.1) | Inquiry |
| MiUTR1M-03743 | DDR1 miRNA 3'UTR clone | Inquiry |
| MiUTR1M-03744 | DDR1 miRNA 3'UTR clone | Inquiry |
| CDCR377983 | Rat Ddr1 ORF Clone(NM_013137.2) | Inquiry |
| CDCR281678 | Human DDR1 ORF Clone(NM_001954.4) | Inquiry |
| CDCR243897 | Mouse Ddr1 ORF Clone(NM_007584.2) | Inquiry |
| CDCR054270 | Human DDR1 ORF clone (NM_013994.2) | Inquiry |
| CDCR054268 | Human DDR1 ORF clone (NM_001202521.1) | Inquiry |
| CDCR054266 | Human DDR1 ORF clone (NM_001202522.1) | Inquiry |
| CDCR054264 | Human DDR1 ORF clone (NM_001202523.1) | Inquiry |
| CDCL183899 | Human DDR1 ORF clone(NM_013993.2) | Inquiry |
DDR1 (Discoidin Domain Receptor Tyrosine Kinase 1) is a receptor tyrosine kinase that belongs to the DDR (Discoidin Domain Receptor) family. It is widely expressed in various tissues and plays a crucial role in regulating cell proliferation, migration, and differentiation. This article aims to provide an overview of DDR1 gene structure, function, and its implications in various physiological and pathological processes.
The DDR1 gene is located on chromosome 6p21.3 and spans approximately 100 kb. It consists of 21 exons and encodes a protein of approximately 140 kDa. The encoded protein contains a signal peptide, a discoidin domain, a tyrosine kinase domain, and a carboxy-terminal tail. The discoidin domain is responsible for ligand binding, while the tyrosine kinase domain is involved in intracellular signaling.
DDR1 functions as a cell surface receptor that binds to various extracellular matrix proteins, including collagen, fibronectin, and laminin. Upon ligand binding, DDR1 undergoes dimerization and autophosphorylation, leading to the activation of downstream signaling pathways. Some of the major signaling pathways regulated by DDR1 include the mitogen-activated protein kinase (MAPK) pathway, the phosphatidylinositol 3-kinase (PI3K) pathway, and the Src family kinase pathway.
Fig1. DDR1-ECD (blue oval)-remodelled collagen fibres (red curvy lines) forming an immune-excluding barrier. The intracellular region of DDR1 (yellow ovals) triggers downstream signal transduction.
DDR1 promotes cell proliferation by regulating the MAPK pathway, which is essential for cell growth and division. Activated DDR1 phosphorylates and activates Raf, a component of the MAPK pathway, leading to the subsequent activation of MEK and ERK. ERK phosphorylates various substrates, including cyclin D1, cyclin E, and Rb, promoting cell cycle progression.
DDR1 also plays a critical role in cell migration by regulating the PI3K pathway. Upon DDR1 activation, PI3K is recruited to the plasma membrane and phosphorylates PIP2, generating PIP3. PIP3 binds to the pleckstrin homology domain of AKT, promoting its activation. AKT phosphorylates various substrates, including GSK3β and paxillin, which are involved in cytoskeletal rearrangement and cell migration.
In addition to promoting cell proliferation and migration, DDR1 also plays a role in cell differentiation. It has been shown that DDR1 activation promotes the differentiation of various cell types, including osteoblasts, chondrocytes, and fibroblasts. This is achieved by regulating the expression of specific transcription factors, such as Runx2 and Sox9, which are essential for cell differentiation.
DDR1 has been implicated in various pathological processes, including cancer, fibrosis, and inflammation. In cancer, DDR1 is often overexpressed and promotes tumor growth, invasion, and metastasis. DDR1 activation has also been linked to the development of fibrosis, a condition characterized by excessive collagen deposition and tissue scarring. Inflammation, another pathological condition, is also regulated by DDR1, as it modulates the recruitment and activation of immune cells.
In conclusion, DDR1 is a versatile regulator of cell signaling that plays a crucial role in cell proliferation, migration, and differentiation. Its involvement in various physiological and pathological processes highlights the importance of understanding its function and mechanism.
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