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DMP1

Official Full Name
dentin matrix acidic phosphoprotein 1
Background
Dentin matrix protein 1, also known as DMP-1, is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in DMP-1 are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia.
Synonyms
DMP1; dentin matrix acidic phosphoprotein 1; dentin matrix acidic phosphoprotein; dentin matrix protein 1; ARHP; ARHR; DMP-1

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