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DMP1


Official Full Name
dentin matrix acidic phosphoprotein 1
Organism
Homo sapiens
Gene ID
1758
Background
Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Synonyms
ARHP; ARHR; DMP-1

Cat.No. Product Name Price
SHH008309 shRNA set against Rat Dmp1(NM_203493.3) Inquiry
SHH008327 shRNA set against Mouse Dmp1(NM_016779.2) Inquiry
SHH278833 shRNA set against Human DMP1 (NM_004407.3) Inquiry
SHH278837 shRNA set against Mouse DMP1 (NM_016779.2) Inquiry
SHH278841 shRNA set against Rat DMP1 (NM_203493.3) Inquiry
SHW006059 shRNA set against Chicken DMP1 (NM_206993) Inquiry
Cat.No. Product Name Price
CDCB167534 Chicken DMP1 ORF Clone (NM_206993) Inquiry
CDFL003684 Mouse Dmp1 cDNA Clone(NM_016779.2) Inquiry
CDFR015323 Rat Dmp1 cDNA Clone(NM_203493.3) Inquiry
MiUTR1M-03899 DMP1 miRNA 3'UTR clone Inquiry
MiUTR1R-01515 DMP1 miRNA 3'UTR clone Inquiry
MiUTR3H-03786 DMP1 miRNA 3'UTR clone Inquiry
CDCB190663 Rabbit DMP1 ORF clone (XM_008267618.1) Inquiry
CDCR056132 Human DMP1 ORF clone (NM_001079911.2) Inquiry
CDCR056136 Mouse Dmp1 ORF clone (NM_016779.2) Inquiry
CDCR382399 Rat Dmp1 ORF Clone(NM_203493.3) Inquiry
CDCS407282 Human DMP1 ORF Clone (BC130581) Inquiry
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