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DLAT


Official Full Name
dihydrolipoamide S-acetyltransferase
Organism
Homo sapiens
Gene ID
1737
Background
This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.[provided by RefSeq, Oct 2009]
Synonyms
E2; PBC; DLTA; PDCE2; PDC-E2

Cat.No. Product Name Price
SHH006333 shRNA set against Rat Dlat(NM_031025.1) Inquiry
SHH278397 shRNA set against Human DLAT (NM_001931.4) Inquiry
SHH278401 shRNA set against Mouse DLAT (NM_145614.4) Inquiry
SHH278405 shRNA set against Rat DLAT (NM_031025.1) Inquiry
SHW017829 shRNA set against Danio rerio DLAT (NM_212667) Inquiry
Cat.No. Product Name Price
CDFR012501 Rat Dlat cDNA Clone(NM_031025.1) Inquiry
MiUTR1R-01500 DLAT miRNA 3'UTR clone Inquiry
MiUTR3H-10217 DLAT miRNA 3'UTR clone Inquiry
CDCB158527 Human DLAT ORF clone (BC039084) Inquiry
CDCB179304 Danio rerio DLAT ORF Clone (NM_212667) Inquiry
CDCB188336 Rabbit DLAT ORF clone (XM_002708446.2) Inquiry
CDCR379523 Rat Dlat ORF Clone(NM_031025.1) Inquiry
CDCS410523 Human DLAT ORF Clone (BC039084) Inquiry
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