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DIO3


Official Full Name
iodothyronine deiodinase 3
Organism
Homo sapiens
Gene ID
1735
Background
The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in pregnant uterus, placenta, fetal and neonatal tissues, and thought to prevent premature exposure of developing fetal tissues to adult levels of thyroid hormones. It regulates circulating fetal thyroid hormone concentrations, and thus plays a critical role in mammalian development. Knockout mice lacking this gene exhibit abnormalities related to development and reproduction, and increased activity of this enzyme in infants with hemangiomas causes severe hypothyroidism. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, May 2016]
Synonyms
D3; 5DIII; TXDI3; DIOIII

Cat.No. Product Name Price
SHH005635 shRNA set against Human DIO3(NM_001362.3) Inquiry
SHH005663 shRNA set against Mouse Dio3(NM_172119.2) Inquiry
SHH278133 shRNA set against Human DIO3 (NM_001362.3) Inquiry
SHH278137 shRNA set against Mouse DIO3 (NM_172119.2) Inquiry
SHH278141 shRNA set against Rat DIO3 (NM_017210.3) Inquiry
SHW002775 shRNA set against Chicken DIO3 (NM_001122648) Inquiry
Cat.No. Product Name Price
CDFH005085 Human DIO3 cDNA Clone(NM_001362.3) Inquiry
CDFL003640 Mouse Dio3 cDNA Clone(NM_172119.2) Inquiry
CDFR011261 Rat Dio3 cDNA Clone(NM_017210.3) Inquiry
MiUTR1H-02831 DIO3 miRNA 3'UTR clone Inquiry
MiUTR1M-03868 DIO3 miRNA 3'UTR clone Inquiry
CDCB164250 Chicken DIO3 ORF Clone (NM_001122648) Inquiry
CDCB183557 Rabbit DIO3 ORF clone (XM_008248683.1) Inquiry
CDCR055610 Human DIO3 ORF clone (NM_001362.3) Inquiry
CDCR055614 Mouse Dio3 ORF clone (NM_172119.2) Inquiry
CDCR378275 Rat Dio3 ORF Clone(NM_017210.3) Inquiry
CDCS410245 Human DIO3 ORF Clone (BC017717) Inquiry
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