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CRKRS

Official Full Name
cyclin dependent kinase 12
Organism
Homo sapiens
GeneID
51755
Background
Enables RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin binding activity. Involved in several processes, including positive regulation of transcription elongation by RNA polymerase II; protein autophosphorylation; and regulation of MAP kinase activity. Located in nuclear speck. Part of cyclin K-CDK12 complex. Biomarker of gastric adenocarcinoma; hepatocellular carcinoma; and stomach cancer. [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
CDK12; CRK7; CRKR; CRKRS;

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