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COL4A1


Official Full Name
collagen type IV alpha 1 chain
Organism
Homo sapiens
Gene ID
1282
Background
This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Synonyms
BSVD; BSVD1; RATOR; PADMAL; COL4A1s

Cat.No. Product Name Price
SHH267265 shRNA set against Mouse Col4a1 (NM_009931.2) Inquiry
SHG190267 shRNA set against Human COL4A1(NM_001845.4) Inquiry
SHG190357 shRNA set against Mouse Col4a1(NM_009931.2) Inquiry
SHH267261 shRNA set against Human Col4a1 (NM_001845.4) Inquiry
SHH267269 shRNA set against Rat Col4a1 (NM_001135009.1) Inquiry
SHW002910 shRNA set against Chicken COL4A1 (NM_001162399) Inquiry
Cat.No. Product Name Price
CDCR248134 Mouse Col4a1 ORF Clone(NM_009931.2) Inquiry
CDCR377099 Rat Col4a1 ORF Clone(NM_001135009.1) Inquiry
CDFL002950 Mouse Col4a1 cDNA Clone(NM_009931.2) Inquiry
CDFR010098 Rat Col4a1 cDNA Clone(NM_001135009.1) Inquiry
MiUTR1H-02321 COL4A1 miRNA 3'UTR clone Inquiry
MiUTR1M-03203 COL4A1 miRNA 3'UTR clone Inquiry
SKO0010 COL4A1 Validated sgRNA vector Inquiry
CDCB164385 Chicken COL4A1 ORF Clone (NM_001162399) Inquiry
CDCB182954 Rabbit COL4A1 ORF clone (XM_008260181.1) Inquiry
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