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CHEK2


Official Full Name
checkpoint kinase 2
Organism
Homo sapiens
Gene ID
11200
Background
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Synonyms
CDS1; CHK2; LFS2; RAD53; TPDS4; hCds1; HuCds1; PP1425

Cat.No. Product Name Price
SHG166170 shRNA set against Mouse Chek2(NM_016681.3) Inquiry
SHG166019 shRNA set against Human CHEK2(NM_007194.3) Inquiry
SHG166141 shRNA set against Human CHEK2(NM_001005735.1) Inquiry
SHG166159 shRNA set against Human CHEK2(NM_145862.2) Inquiry
SHG174457 shRNA set against Rat Chek2(NM_053677.1) Inquiry
SHH262961 shRNA set against Human CHEK2 (NM_007194.3) Inquiry
SHH262965 shRNA set against Mouse CHEK2 (NM_016681.3) Inquiry
SHH262969 shRNA set against Rat CHEK2 (NM_053677.1) Inquiry
SHW002546 shRNA set against Chicken CHEK2 (NM_001080107) Inquiry
SHW016286 shRNA set against Danio rerio CHEK2 (NM_200045) Inquiry
Cat.No. Product Name Price
CDFH003582 Human CHEK2 cDNA Clone(NM_001005735.1) Inquiry
MiUTR1R-00963 CHEK2 miRNA 3'UTR clone Inquiry
MiUTR1M-02994 CHEK2 miRNA 3'UTR clone Inquiry
MiUTR1H-02112 CHEK2 miRNA 3'UTR clone Inquiry
MiUTR1H-02111 CHEK2 miRNA 3'UTR clone Inquiry
CDFR013388 Rat Chek2 cDNA Clone(NM_053677.1) Inquiry
CDFH003584 Human CHEK2 cDNA Clone(NM_007194.3) Inquiry
CDFH003583 Human CHEK2 cDNA Clone(NM_007194.3) Inquiry
SKO0064 CHEK2 Validated sgRNA vector Inquiry
CDFG009115 Human CHEK2 cDNA Clone(NM_145862.2) Inquiry
CDCR339891 Human CHEK2 ORF Clone(NM_001005735.1) Inquiry
MiUTR3H-06757 CHEK2 miRNA 3'UTR clone Inquiry
CDCS406255 Human CHEK2 ORF Clone (BC004207) Inquiry
CDCR380475 Rat Chek2 ORF Clone(NM_053677.1) Inquiry
CDCR045608 Human CHEK2 ORF clone (NM_145862.2) Inquiry
CDCB193967 Rabbit CHEK2 ORF clone (XM_008274621.1) Inquiry
CDCB177761 Danio rerio CHEK2 ORF Clone (NM_200045) Inquiry
CDCB164021 Chicken CHEK2 ORF Clone (NM_001080107) Inquiry
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