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CHCHD2


Official Full Name
coiled-coil-helix-coiled-coil-helix domain containing 2
Organism
Homo sapiens
Gene ID
51142
Background
The protein encoded by this gene belongs to a class of eukaryotic CX(9)C proteins characterized by four cysteine residues spaced ten amino acids apart from one another. These residues form disulfide linkages that define a CHCH fold. In response to stress, the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 nucleotide oxygen responsive element in the promoter of cytochrome oxidase 4I2, a subunit of the terminal enzyme of the electron transport chain. In concert with recombination signal sequence-binding protein J, binding of this protein activates the oxygen responsive element at four percent oxygen. In addition, it has been shown that this protein is a negative regulator of mitochondria-mediated apoptosis. In response to apoptotic stimuli, mitochondrial levels of this protein decrease, allowing BCL2-associated X protein to oligomerize and activate the caspase cascade. Pseudogenes of this gene are found on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Synonyms
MNRR1; NS2TP; MIX17B; PARK22; C7orf17

Cat.No. Product Name Price
SHG173467 shRNA set against Human CHCHD2(NM_016139.2) Inquiry
SHG173557 shRNA set against Mouse Chchd2(NM_024166.6) Inquiry
SHH262741 shRNA set against Rat CHCHD2 (NM_001015019.1) Inquiry
SHW000308 shRNA set against Chicken CHCHD2 (NM_001006218) Inquiry
SHW016916 shRNA set against Danio rerio CHCHD2 (NM_200767) Inquiry
Cat.No. Product Name Price
CDCR256348 Mouse Chchd2 ORF Clone(NM_024166.6) Inquiry
CDCS414183 Human CHCHD2 ORF Clone (BC003079) Inquiry
CDFG000168 Human CHCHD2 cDNA Clone(NM_016139.2) Inquiry
CDFR003417 Rat Chchd2 cDNA Clone(NM_001015019.1) Inquiry
MiUTR1H-02094 CHCHD2 miRNA 3'UTR clone Inquiry
MiUTR1M-02985 CHCHD2 miRNA 3'UTR clone Inquiry
MiUTR1R-00959 CHCHD2 miRNA 3'UTR clone Inquiry
SKO0381 CHCHD2 Validated sgRNA vector Inquiry
CDCB159341 Human CHCHD2 ORF clone (BC003079) Inquiry
CDCB161783 Chicken CHCHD2 ORF Clone (NM_001006218) Inquiry
CDCB178391 Danio rerio CHCHD2 ORF Clone (NM_200767) Inquiry
CDCB190057 Rabbit CHCHD2 ORF clone (XM_002722282.2) Inquiry
CDCR300654 Human CHCHD2 ORF Clone(NM_016139.2) Inquiry
CDCR370446 Rat Chchd2 ORF Clone(NM_001015019.1) Inquiry
CDCS414184 Human CHCHD2 ORF Clone (BC066331) Inquiry
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