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CENPJ


Official Full Name
centrosome assembly and centriole elongation protein
Organism
Homo sapiens
Gene ID
55835
Background
This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and cognitive disability. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
Synonyms
CPAP; LAP; LIP1; BM032; CENPJ; MCPH6; SASS4; SCKL4; Sas-4; CENP-J

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