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CDK5R1


Official Full Name
cyclin dependent kinase 5 regulatory subunit 1
Organism
Homo sapiens
Gene ID
8851
Background
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008]
Synonyms
p23; p25; p35; CDK5R; NCK5A; CDK5P35; p35nck5a

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AD03473Z Human CDK5R1 adenoviral particles Inquiry
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SHG164647 shRNA set against Human CDK5R1(NM_003885.2) Inquiry
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CDFH003323 Human CDK5R1 cDNA Clone(NM_003885.2) Inquiry
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MiUTR1H-01985 CDK5R1 miRNA 3'UTR clone Inquiry
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MiUTR1R-00908 CDK5R1 miRNA 3'UTR clone Inquiry
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CDCB186761 Rabbit CDK5R1 ORF clone (XM_008271068.1) Inquiry
CDCL183504 Human CDK5R1 ORF clone(NM_003885.2) Inquiry
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CDCS411529 Human CDK5R1 ORF Clone (BC026347) Inquiry
CDCS411530 Human CDK5R1 ORF Clone (BC020580) Inquiry
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