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C4BPB

Official Full Name
complement component 4 binding protein, beta
Background
This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.
Synonyms
C4BP; C4b-binding protein beta chain; complement component 4 binding protein, beta; OTTHUMP00000034288; OTTHUMP00000034289; OTTHUMP00000034374; OTTHUMP00000034375; C4b binding protein, beta chain; complement component 4 binding protein, beta chain; complement component 4-binding protein, beta; C4b-binding protein, beta chain; C4BPB; C4BP, complement component 4 binding protein, beta; C4b binding protein; beta chain; complement component 4 binding protein

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