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BARD1


Official Full Name
BRCA1 associated RING domain 1
Organism
Homo sapiens
Gene ID
580
Background
This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Synonyms
CFAP96; C4orf47

Cat.No. Product Name Price
AD01711Z Human BARD1 adenoviral particles Inquiry
Cat.No. Product Name Price
SHG034129 shRNA set against Mouse Bard1(NM_007525.3) Inquiry
SHG034147 shRNA set against Human BARD1(NM_000465.2) Inquiry
SHG034183 shRNA set against Rat Bard1(NM_022622.1) Inquiry
SHH244874 shRNA set against Human BARD1 (NM_000465.2) Inquiry
SHH244878 shRNA set against Mouse BARD1 (NM_007525.3) Inquiry
SHH244882 shRNA set against Rat BARD1 (NM_022622.1) Inquiry
SHW001847 shRNA set against Chicken BARD1 (NM_001031246) Inquiry
Cat.No. Product Name Price
CDCB157726 Human BARD1 ORF clone (BC126426) Inquiry
CDFR012053 Rat Bard1 cDNA Clone(NM_022622.1) Inquiry
MiUTR1H-00805 BARD1 miRNA 3'UTR clone Inquiry
MiUTR1M-01973 BARD1 miRNA 3'UTR clone Inquiry
MiUTR1R-00513 BARD1 miRNA 3'UTR clone Inquiry
CDCB163322 Chicken BARD1 ORF Clone (NM_001031246) Inquiry
CDCB193073 Rabbit BARD1 ORF clone (XM_008259118.1) Inquiry
CDCR033178 Mouse Bard1 ORF clone (NM_007525.3) Inquiry
CDCR379100 Rat Bard1 ORF Clone(NM_022622.1) Inquiry
CDCS405677 Human BARD1 ORF Clone (BC126426) Inquiry
CDCS405678 Human BARD1 ORF Clone (BC126428) Inquiry
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