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ARHGEF12

Official Full Name
Rho guanine nucleotide exchange factor 12
Organism
Homo sapiens
GeneID
23365
Background
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Synonyms
LARG; PRO2792;

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