Pages
Products

APPL2


Official Full Name
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
Organism
Homo sapiens
Gene ID
55198
Background
The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011]
Synonyms
DIP13B

Cat.No. Product Name Price
SHG066717 shRNA set against Human APPL2(NM_018171.3) Inquiry
SHG066732 shRNA set against Mouse Appl2(NM_145220.2) Inquiry
SHH238762 shRNA set against Human APPL2 (NM_018171.3) Inquiry
SHH238766 shRNA set against Mouse APPL2 (NM_145220.2) Inquiry
SHH238770 shRNA set against Rat APPL2 (NM_001108741.1) Inquiry
SHW012689 shRNA set against Danio rerio APPL2 (NM_001128075) Inquiry
Cat.No. Product Name Price
CDCR029102 Human APPL2 ORF clone (NM_001251905.1) Inquiry
CDFR008329 Rat Appl2 cDNA Clone(NM_001108741.1) Inquiry
MiUTR1H-00493 APPL2 miRNA 3'UTR clone Inquiry
MiUTR1M-01597 APPL2 miRNA 3'UTR clone Inquiry
CDCB174164 Danio rerio APPL2 ORF Clone (NM_001128075) Inquiry
CDCB188322 Rabbit APPL2 ORF clone (XM_008257119.1) Inquiry
CDCH016435 Mouse APPL2 ORF clone(NM_145220.2) Inquiry
CDCR029100 Human APPL2 ORF clone (NM_001251904.1) Inquiry
CDCR303192 Human APPL2 ORF Clone(NM_018171.3) Inquiry
CDCR375372 Rat Appl2 ORF Clone(NM_001108741.1) Inquiry
CDCS409945 Human APPL2 ORF Clone (BC033731) Inquiry
Quick Inquiry