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ALS2


Official Full Name
alsin Rho guanine nucleotide exchange factor ALS2
Organism
Homo sapiens
Gene ID
57679
Background
The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Synonyms
ALSJ; PLSJ; IAHSP; ALS2CR6

Cat.No. Product Name Price
SHG054631 shRNA set against Rat Als2(NM_001013413.1) Inquiry
SHG054685 shRNA set against Human ALS2(NM_020919.3) Inquiry
SHH235510 shRNA set against Human ALS2 (NM_020919.3) Inquiry
SHH235514 shRNA set against Mouse ALS2 (NM_028717.6) Inquiry
SHH235518 shRNA set against Rat ALS2 (NM_001013413.1) Inquiry
Cat.No. Product Name Price
CDCR261737 Mouse Als2 ORF Clone(NM_028717.6) Inquiry
CDFH000694 Human ALS2 cDNA Clone(NM_001135745.1) Inquiry
CDFR002922 Rat Als2 cDNA Clone(NM_001013413.1) Inquiry
MiUTR1R-00240 ALS2 miRNA 3'UTR clone Inquiry
MiUTR3H-08389 ALS2 miRNA 3'UTR clone Inquiry
MiUTR3H-08390 ALS2 miRNA 3'UTR clone Inquiry
CDCB190238 Rabbit ALS2 ORF clone (XM_008258979.1) Inquiry
CDCR026984 Human ALS2 ORF clone (NM_001135745.1) Inquiry
CDCR026986 Mouse Als2 ORF clone (NM_001159948.2) Inquiry
CDCR026988 Mouse Als2 ORF clone (NM_146109.3) Inquiry
CDCR026998 Human ALS2 ORF clone (NM_020919.3) Inquiry
CDCR370010 Rat Als2 ORF Clone(NM_001013413.1) Inquiry
CDCS408124 Human ALS2 ORF Clone (BC029174) Inquiry
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