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ACE


Official Full Name
angiotensin I converting enzyme
Organism
Homo sapiens
Gene ID
1636
Background
This gene encodes an enzyme involved in blood pressure regulation and electrolyte balance. It catalyzes the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This angiotensin converting enzyme (ACE) also inactivates the vasodilator protein, bradykinin. Accordingly, the encoded enzyme increases blood pressure and is a drug target of ACE inhibitors, which are often prescribed to reduce blood pressure. This enzyme additionally plays a role in fertility through its ability to cleave and release GPI-anchored membrane proteins in spermatozoa. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme. This polymorphism, as well as mutations in this gene, have been implicated in a wide variety of diseases including cardiovascular pathophysiologies, psoriasis, renal disease, stroke, and Alzheimer's disease. Regulation of the homologous ACE2 gene may be involved in progression of disease caused by several human coronaviruses, including SARS-CoV and SARS-CoV-2. Alternative splicing results in multiple transcript variants encoding both somatic (sACE) and male-specific testicular (tACE) isoforms. [provided by RefSeq, Sep 2020]
Synonyms
A2D; A2LG; A2LP; A2RP

Cat.No. Product Name Price
AD00536Z Human ACE adenoviral particles Inquiry
Cat.No. Product Name Price
SHG029257 shRNA set against Rat Ace(NM_012544.1) Inquiry
SHH230206 shRNA set against Human ACE (NM_000789.3) Inquiry
SHH230210 shRNA set against Mouse ACE (NM_009598.2) Inquiry
SHW002965 shRNA set against Chicken ACE (NM_001167732) Inquiry
Cat.No. Product Name Price
CDCB160337 Human ACE ORF clone (NM_000789.2) Inquiry
CDCL182529 Rat ACE ORF clone(NM_012544.1) Inquiry
CDFH000176 Human ACE cDNA Clone(NM_001178057.1) Inquiry
CDFR010364 Rat Ace cDNA Clone(NM_012544.1) Inquiry
MiUTR1R-00066 ACE miRNA 3'UTR clone Inquiry
MiUTR3H-00147 ACE miRNA 3'UTR clone Inquiry
MiUTR3H-00148 ACE miRNA 3'UTR clone Inquiry
CDCB164440 Chicken ACE ORF Clone (NM_001167732) Inquiry
CDCB180227 Rabbit ACE ORF clone (NM_001082395.1) Inquiry
CDCH014727 Mouse ACE ORF clone(NM_207624.5) Inquiry
CDCR023698 Human ACE ORF clone (NM_001178057.1) Inquiry
CDCR247531 Mouse Ace ORF Clone(NM_009598.2) Inquiry
CDCR320021 Human ACE ORF Clone(NM_152830.2) Inquiry
CDCR337681 Human ACE ORF Clone(NM_000789.3) Inquiry
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