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ATP6V0A1

Official Full Name
ATPase, H+ transporting, lysosomal V0 subunit a1
Background
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene.
Synonyms
ATP6V0A1; ATPase, H+ transporting, lysosomal V0 subunit a1; ATP6N1, ATP6N1A, ATPase, H+ transporting, lysosomal (vacuolar proton pump) non catalytic accessory protein 1A (110/116kD) , ATPase, H+ transporting, lysosomal V0 subunit a isoform 1 , ATPase, H+ transporting, lysosomal V0 subunit A1 , VPP1; V-type proton ATPase 116 kDa subunit a isoform 1; a1; Stv1; Vph1; ATP6N1; ATP6N1A; ATPase H+ transporting lysosomal (vacuolar proton pump) non catalytic accessory protein 1A (110/116kD); ATPase H+ transporting lysosomal non catalytic accessory protein 1 (110/116kD); ATPase H+ transporting lysosomal V0 subunit a1; Clathrin coated vesicle/synaptic vesicle proton pump 116 kDa subunit; Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; DKFZp781J1951; H(+) transporting two sector ATPase 116 kDa accessory protein A1; V ATPase 116 kDa; V ATPase 116 kDa isoform a1; V type proton ATPase 116 kDa subunit a; V type proton ATPase 116 kDa subunit a isoform 1; V-ATPase 116 kDa isoform a1; Vacuolar adenosine triphosphatase subunit Ac116; Vacuolar proton pump subunit 1; Vacuolar proton pump, subunit 1; Vacuolar proton translocating ATPase 116 kDa subunit A; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1; Vacuolar type H(+) ATPase 115 kDa subunit; VPP1; VPP1_HUMAN; V-ATPase 116 kDa; V-type proton ATPase 116 kDa subunit a; vacuolar-type H(+)-ATPase 115 kDa subunit; H(+)-transporting two-sector ATPase, 116 kDa accessory protein A1; ATPase, H+ transporting, lysosomal non-catalytic accessory protein 1 (110/116kD); ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1A (110/116kD); vacuolar H(+)-transporting

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