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ASAH2

Official Full Name
N-acylsphingosine amidohydrolase 2
Organism
Homo sapiens
GeneID
56624
Background
Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger (see MIM 603730) (Mitsutake et al., 2001 [PubMed 11328816]).[supplied by OMIM, Mar 2008]
Synonyms
HNAC1; BCDase; LCDase; NCDase; N-CDase;

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