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ARHGAP35

Official Full Name
Rho GTPase activating protein 35
Background
The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids.
Synonyms
glucocorticoid receptor DNA binding factor 1; Rho GAP p190A; ARHGAP35; Rho GTPase-activating protein 35; GRF-1; MGC10745; KIAA1722; P190-A; P190A; glucocorticoid receptor DNA-binding factor 1; p190ARhoGAP; GRF1; p190RhoGAP; Glucocorticoid receptor repression factor 1; GRLF1; Rho GTPase activating protein 35

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