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APC2


Official Full Name
APC regulator of WNT signaling pathway 2
Organism
Homo sapiens
Gene ID
10297
Background
This gene encodes a strongly conserved protein that has an N-terminal coiled-coil domain followed by an armadillo domain, five 20-amino acid repeats, and two SAMP domains. This protein promotes the assembly of a multiprotein complex that recruits and phosphorylates the Wnt effector beta-catenin and targets beta-catenin for ubiquitylation and proteasomal degradation. This protein therefore plays a role in the reduction of cytoplasmic levels of beta-catenin which in turn reduces activation of Wnt target genes that play a pivotal role in the pathogenesis of various human cancers. The protein encoded by this gene is closely related to the adenomatous polyposis coli (APC) tumor-suppressor protein and has similar tumor-suppressor effects. This gene also plays a role in actin assembly, cell-cell adhesion, and microtubule network formation through its interaction with cytoskeletal proteins. This gene has its highest expression in the central nervous system and is involved in brain development through cytoskeletal regulation in neurons. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017]
Synonyms
APCL; MRT74

Cat.No. Product Name Price
SHG064081 shRNA set against Human APC2(NM_005883.2) Inquiry
SHG064153 shRNA set against Mouse Apc2(NM_011789.2) Inquiry
SHH236118 shRNA set against Human ANAPC2 (NM_013366.3) Inquiry
SHH236122 shRNA set against Mouse ANAPC2 (NM_175300.4) Inquiry
SHH236126 shRNA set against Rat ANAPC2 (NM_001100532.1) Inquiry
SHH238118 shRNA set against Human APC2 (NM_005883.2) Inquiry
SHH238122 shRNA set against Mouse APC2 (NM_011789.2) Inquiry
SHH238126 shRNA set against Rat APC2 (NM_001106769.2) Inquiry
SHH409560 shRNA set against Human SLC25A23 (NM_024103.2) Inquiry
SHH409564 shRNA set against Mouse SLC25A23 (NM_025877.4) Inquiry
SHH409568 shRNA set against Rat SLC25A23 (NM_001106873.2) Inquiry
SHW003005 shRNA set against Chicken APC2 (NM_001171771) Inquiry
SHW014083 shRNA set against Danio rerio ANAPC2 (NM_001256746) Inquiry
Cat.No. Product Name Price
SKO0779 SLC25A23 Validated sgRNA vector Inquiry
MiUTR1H-09480 SLC25A23 miRNA 3'UTR clone Inquiry
MiUTR1H-00461 APC2 miRNA 3'UTR clone Inquiry
MiUTR1H-00356 ANAPC2 miRNA 3'UTR clone Inquiry
CDFR006498 Rat Apc2 cDNA Clone(NM_001106769.2) Inquiry
CDFR005087 Rat Anapc2 cDNA Clone(NM_001100532.1) Inquiry
CDFL001317 Mouse Apc2 cDNA Clone(NM_011789.2) Inquiry
CDCR291525 Human APC2 ORF Clone(NM_005883.2) Inquiry
CDFH000945 Human APC2 cDNA Clone(NM_005883.2) Inquiry
CDFH000768 Human ANAPC2 cDNA Clone(NM_013366.3) Inquiry
CDFH000767 Human ANAPC2 cDNA Clone(NM_013366.3) Inquiry
CDFG021687 Mouse 2300003K06Rik cDNA Clone(NM_001195383.1) Inquiry
CDFG004257 Human SLC25A23 cDNA Clone(NM_024103.2) Inquiry
MiUTR1M-01566 APC2 miRNA 3'UTR clone Inquiry
CDCS415673 Human SLC25A23 ORF Clone (BC001656) Inquiry
CDCR373651 Rat Slc25a23 ORF Clone(NM_001106873.2) Inquiry
CDCR373510 Rat Apc2 ORF Clone(NM_001106769.2) Inquiry
CDCR372309 Rat Anapc2 ORF Clone(NM_001100532.1) Inquiry
CDCR296507 Human ANAPC2 ORF Clone(NM_013366.3) Inquiry
CDCR272806 Mouse Anapc2 ORF Clone(NM_175300.4) Inquiry
CDCR251310 Mouse Apc2 ORF Clone(NM_011789.2) Inquiry
CDCR028726 Human SLC25A23 ORF clone (NM_024103.2) Inquiry
CDCR020186 Mouse 2300003K06Rik ORF clone (NM_001195383.1) Inquiry
CDCH400767 Mouse SLC25A23 ORF clone(NM_025877.4) Inquiry
CDCB175558 Danio rerio ANAPC2 ORF Clone (NM_001256746) Inquiry
CDCS413426 Human ANAPC2 ORF Clone (BC032503) Inquiry
CDCB164480 Chicken APC2 ORF Clone (NM_001171771) Inquiry
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