Pages
Products

ANK1


Official Full Name
ankyrin 1
Organism
Homo sapiens
Gene ID
286
Background
Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq, Dec 2008]
Synonyms
ANK; SPH1; SPH2; ankyrin-1

Cat.No. Product Name Price
SHG058339 shRNA set against Human ANK1(NM_020475.2) Inquiry
SHG058375 shRNA set against Human ANK1(NM_020476.2) Inquiry
SHG058393 shRNA set against Human ANK1(NM_000037.3) Inquiry
SHG058411 shRNA set against Mouse Ank1(NM_031158.2) Inquiry
SHG058489 shRNA set against Human ANK1(NM_020477.2) Inquiry
SHH236342 shRNA set against Human ANK1 (NM_000037.3) Inquiry
SHH236346 shRNA set against Mouse ANK1 (NM_031158.2) Inquiry
SHH236350 shRNA set against Rat ANK1 (NM_001107322.2) Inquiry
Cat.No. Product Name Price
MiUTR4H-TG00321 ANK1 miRNA 3'UTR clone Inquiry
MiUTR1H-00371 ANK1 miRNA 3'UTR clone Inquiry
MiUTR1H-00370 ANK1 miRNA 3'UTR clone Inquiry
CDCR027562 Human ANK1 ORF clone (NM_000037.3) Inquiry
MiUTR1H-00369 ANK1 miRNA 3'UTR clone Inquiry
CDFR007038 Rat Ank1 cDNA Clone(NM_001107322.2) Inquiry
CDFL001207 Mouse Ank1 cDNA Clone(NM_031158.2) Inquiry
CDFH000789 Human ANK1 cDNA Clone(NM_001142445.1) Inquiry
CDFH000788 Human ANK1 cDNA Clone(NM_001142446.1) Inquiry
CDFH000787 Human ANK1 cDNA Clone(NM_000037.3) Inquiry
CDFG019059 Mouse Ank1 cDNA Clone(NM_001110783.1) Inquiry
CDFG002755 Human ANK1 cDNA Clone(NM_020477.2) Inquiry
CDFG002754 Human ANK1 cDNA Clone(NM_020476.2) Inquiry
MiUTR1M-01465 ANK1 miRNA 3'UTR clone Inquiry
CDFG002753 Human ANK1 cDNA Clone(NM_020475.2) Inquiry
CDCS405368 Human ANK1 ORF Clone (BC007930) Inquiry
CDCR374037 Rat Ank1 ORF Clone(NM_001107322.2) Inquiry
CDCR305543 Human ANK1 ORF Clone(NM_020480.4) Inquiry
CDCR305541 Human ANK1 ORF Clone(NM_020478.4) Inquiry
CDCR263764 Mouse Ank1 ORF Clone(NM_031158.2) Inquiry
CDCR027570 Human ANK1 ORF clone (NM_001142445.1) Inquiry
CDCR027568 Human ANK1 ORF clone (NM_001142446.1) Inquiry
CDCR027566 Human ANK1 ORF clone (NM_020475.2) Inquiry
CDCR027564 Human ANK1 ORF clone (NM_020476.2) Inquiry
CDCR027556 Human ANK1 ORF clone (NM_020477.2) Inquiry
CDCR027550 Mouse Ank1 ORF clone (NM_001110783.1) Inquiry
CDCS405367 Human ANK1 ORF Clone (BC030957) Inquiry
CDCB183772 Rabbit ANK1 ORF clone (XM_008274002.1) Inquiry
Quick Inquiry