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ALOXE3


Official Full Name
arachidonate epidermal lipoxygenase 3
Organism
Homo sapiens
Gene ID
59344
Background
This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Synonyms
LI5; ARCI3; E-LOX; eLOX3; eLOX-3

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SHH235414 shRNA set against Human ALOXE3 (NM_021628.2) Inquiry
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Cat.No. Product Name Price
CDFH000686 Human ALOXE3 cDNA Clone(NM_001165960.1) Inquiry
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CDCR026934 Human ALOXE3 ORF clone (NM_001165960.1) Inquiry
CDCR251306 Mouse Aloxe3 ORF Clone(NM_011786.2) Inquiry
CDCR372613 Rat Aloxe3 ORF Clone(NM_001105793.1) Inquiry
CDCS418010 Human ALOXE3 ORF Clone (BC104724) Inquiry
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