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ALAD

Official Full Name
aminolevulinate dehydratase
Background
The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria.
Synonyms
ALAD; aminolevulinate dehydratase; aminolevulinate, delta , dehydratase; delta-aminolevulinic acid dehydratase; ALADH; PBGS; porphobilinogen synthase; MGC5057; OTTMUSP00000009377; RP11-10I9.1; ALADR; Delta aminolevulinic acid dehydratase; Lv; OTTMUSP00000009376; RP24-189G18.9; aminolevulinate, delta-, dehydratase; zgc:110219; CH73-203I15.1

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