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ADD3


Official Full Name
adducin 3
Organism
Homo sapiens
Gene ID
120
Background
Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known. [provided by RefSeq, Jul 2008]
Synonyms
odr-4; 1810053E15Rik

Cat.No. Product Name Price
SHG041976 shRNA set against Human ADD3(NM_001121.2) Inquiry
SHG041872 shRNA set against Human ADD3(NM_001121.2) Inquiry
SHG041973 shRNA set against Human ADD3(NM_016824.3) Inquiry
SHG041866 shRNA set against Human ADD3(NM_001121.2) Inquiry
SHH232330 shRNA set against Mouse ADD3 (NM_013758.3) Inquiry
SHH232326 shRNA set against Human ADD3 (NM_016824.3) Inquiry
SHG041975 shRNA set against Human ADD3(NM_016824.3) Inquiry
SHG041974 shRNA set against Human ADD3(NM_001121.2) Inquiry
SHG041965 shRNA set against Human ADD3(NM_001121.2) Inquiry
SHG041881 shRNA set against Human ADD3(NM_016824.3) Inquiry
SHG041880 shRNA set against Human ADD3(NM_001121.2) Inquiry
SHG041879 shRNA set against Human ADD3(NM_016824.3) Inquiry
SHG041878 shRNA set against Human ADD3(NM_001121.2) Inquiry
SHG041877 shRNA set against Human ADD3(NM_016824.3) Inquiry
SHG041876 shRNA set against Human ADD3(NM_001121.2) Inquiry
SHG041875 shRNA set against Human ADD3(NM_016824.3) Inquiry
SHG041874 shRNA set against Human ADD3(NM_001121.2) Inquiry
SHG041873 shRNA set against Human ADD3(NM_016824.3) Inquiry
SHG041871 shRNA set against Human ADD3(NM_016824.3) Inquiry
SHG041870 shRNA set against Human ADD3(NM_001121.2) Inquiry
SHG041869 shRNA set against Human ADD3(NM_016824.3) Inquiry
SHG041868 shRNA set against Human ADD3(NM_001121.2) Inquiry
SHG041867 shRNA set against Human ADD3(NM_016824.3) Inquiry
SHH232334 shRNA set against Rat ADD3 (NM_031552.2) Inquiry
SHW004622 shRNA set against Chicken ADD3 (NM_204103) Inquiry
Cat.No. Product Name Price
MiUTR3H-04216 ADD3 miRNA 3'UTR clone Inquiry
MiUTR1H-00191 ADD3 miRNA 3'UTR clone Inquiry
CDFR012710 Rat Add3 cDNA Clone(NM_031552.2) Inquiry
CDFH000370 Human ADD3 cDNA Clone(NM_001121.2) Inquiry
CDFG020562 Mouse Add3 cDNA Clone(NM_001164101.1) Inquiry
CDFG020561 Mouse Add3 cDNA Clone(NM_001164100.1) Inquiry
CDFG002435 Human ADD3 cDNA Clone(NM_019903.3) Inquiry
CDFG000535 Human ADD3 cDNA Clone(NM_016824.3) Inquiry
MiUTR1H-00192 ADD3 miRNA 3'UTR clone Inquiry
CDCS414983 Human ADD3 ORF Clone (BC062559) Inquiry
CDCR379743 Rat Add3 ORF Clone(NM_031552.2) Inquiry
CDCR240309 Mouse Add3 ORF Clone(NM_001164101.1) Inquiry
CDCR240305 Mouse Add3 ORF Clone(NM_001164099.1) Inquiry
CDCR024974 Mouse Add3 ORF clone (NM_001164100.1) Inquiry
CDCR024968 Human ADD3 ORF clone (NM_001121.2) Inquiry
CDCR024966 Human ADD3 ORF clone (NM_016824.3) Inquiry
CDCH015041 Rat ADD3 ORF clone(NM_001164103.1) Inquiry
CDCH015036 Mouse ADD3 ORF clone(NM_013758.3) Inquiry
CDCB186220 Rabbit ADD3 ORF clone (XM_008270495.1) Inquiry
CDCR304854 Human ADD3 ORF Clone(NM_019903.3) Inquiry
CDCB166097 Chicken ADD3 ORF Clone (NM_204103) Inquiry
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