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ACO1


Official Full Name
aconitase 1
Organism
Homo sapiens
Gene ID
48
Background
The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jan 2014]

Cat.No. Product Name Price
AD00546Z Human ACO1 adenoviral particles Inquiry
Cat.No. Product Name Price
SHG029719 shRNA set against Human ACO1(NM_002197.2) Inquiry
SHG029737 shRNA set against Mouse Aco1(NM_007386.2) Inquiry
SHG029755 shRNA set against Rat Aco1(NM_017321.1) Inquiry
SHH230338 shRNA set against Human ACO1 (NM_002197.2) Inquiry
SHH230342 shRNA set against Mouse ACO1 (NM_007386.2) Inquiry
SHH230346 shRNA set against Rat ACO1 (NM_017321.1) Inquiry
SHW001192 shRNA set against Chicken ACO1 (NM_001030536) Inquiry
SHW009344 shRNA set against Danio rerio ACO1 (NM_001034983) Inquiry
Cat.No. Product Name Price
CDCR023796 Mouse Aco1 ORF clone (NM_007386.2) Inquiry
CDFR011036 Rat Aco1 cDNA Clone(NM_017321.1) Inquiry
MiUTR1H-00105 ACO1 miRNA 3'UTR clone Inquiry
MiUTR1M-01115 ACO1 miRNA 3'UTR clone Inquiry
MiUTR1R-00073 ACO1 miRNA 3'UTR clone Inquiry
CDCB162667 Chicken ACO1 ORF Clone (NM_001030536) Inquiry
CDCB170819 Danio rerio ACO1 ORF Clone (NM_001034983) Inquiry
CDCB180322 Rabbit ACO1 ORF clone (XM_008253164.1) Inquiry
CDCL182536 Human ACO1 ORF clone(NM_002197.2) Inquiry
CDCR378422 Rat Aco1 ORF Clone(NM_017321.1) Inquiry
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