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wt1a


Official Full Name
WT1 transcription factor a
Organism
Danio rerio
Gene ID
30245
Background
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including kidney development; regulation of blood-brain barrier permeability; and visceral serous pericardium development. Predicted to be located in cytoplasm and nuclear speck. Is expressed in several structures, including cardiovascular system; central nervous system; mesoderm; renal system; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Denys-Drash syndrome; Frasier syndrome; malignant mesothelioma; nephroblastoma (multiple); and nephrotic syndrome type 4. Orthologous to human WT1 (WT1 transcription factor). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
wt1; zwt1

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