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tph1a


Official Full Name
tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a
Organism
Danio rerio
Gene ID
352943
Background
Predicted to enable tryptophan 5-monooxygenase activity. Acts upstream of or within regulation of hematopoietic stem cell differentiation and response to hypoxia. Predicted to be active in neuron projection. Is expressed in nervous system; neural tube; and ovary. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; borderline personality disorder; depressive disorder (multiple); and nicotine dependence. Orthologous to human TPH1 (tryptophan hydroxylase 1). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
tph; tph1; tphD1; tph1-1

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