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tdp2b


Official Full Name
tyrosyl-DNA phosphodiesterase 2b
Organism
Danio rerio
Gene ID
553516
Background
Enables DNA binding activity and tyrosyl-DNA phosphodiesterase activity. Involved in determination of left/right symmetry and gastrulation. Acts upstream of or within convergent extension involved in gastrulation and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in nucleus. Predicted to be active in PML body and cytoplasm. Is expressed in Kupffer's vesicle; forerunner cell group; and tail bud. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 23. Orthologous to human TDP2 (tyrosyl-DNA phosphodiesterase 2). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
tdp2; ttrap; ttrapl

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