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spi1b


Official Full Name
Spi-1 proto-oncogene b
Organism
Danio rerio
Gene ID
30117
Background
Enables sequence-specific DNA binding activity. Involved in macrophage activation involved in immune response and macrophage differentiation. Acts upstream of or within myeloid cell differentiation; negative regulation of myeloid cell differentiation; and regulation of gene expression. Predicted to be active in nucleus. Is expressed in several structures, including hematopoietic cell; hematopoietic system; mesoderm; trunk; and yolk. Human ortholog(s) of this gene implicated in agammaglobulinemia 10. Orthologous to human SPI1 (Spi-1 proto-oncogene). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
pu1; pu.1; spi1; sfpi1; cb1086; si:by184l24.2

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