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smad6a


Official Full Name
SMAD family member 6a
Organism
Danio rerio
Gene ID
116992
Background
Predicted to enable I-SMAD binding activity and transcription regulator inhibitor activity. Acts upstream of or within heart development; negative regulation of BMP signaling pathway; and negative regulation of SMAD protein signal transduction. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Is expressed in heart primordium; heart rudiment; heart tube; and margin. Human ortholog(s) of this gene implicated in aortic valve disease 2; craniosynostosis 7; and radioulnar synostosis. Orthologous to human SMAD6 (SMAD family member 6). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
madh6; smad6; wu:fb22g05

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