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selt2


Official Full Name
selenoprotein T, 2
Organism
Danio rerio
Gene ID
352917
Background
This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs in vertebrates contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Paralogs of this gene are found on chromosomes 2 (GeneID:352919) and 18 (GeneID:352921). [provided by RefSeq, Aug 2017]
Synonyms
cb699; selt2; sept2; fj34h11; wu:fj34h11; zgc:112046

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