Pages
Products

PTRH2


Official Full Name
peptidyl-tRNA hydrolase 2
Organism
Homo sapiens
Gene ID
51651
Background
The protein encoded by this gene is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix (ECM), but also promotes apoptosis in cells that have lost their attachment to the ECM, a process called anoikos. After loss of cell attachment to the ECM, this protein is phosphorylated, is released from the mitochondria into the cytosol, and promotes caspase-independent apoptosis through interactions with transcriptional regulators. This gene has been implicated in the development and progression of tumors, and mutations in this gene have been associated with an infantile multisystem neurologic, endocrine, and pancreatic disease (INMEPD) characterized by intellectual disability, postnatal microcephaly, progressive cerebellar atrophy, hearing impairment, polyneuropathy, failure to thrive, and organ fibrosis with exocrine pancreas insufficiency (PMID: 25574476). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
Synonyms
PTH; BIT1; PTH2; PTH 2; CFAP37; IMNEPD; CGI-147

Cat.No. Product Name Price
SHH386924 shRNA set against Human PTRH2 (NM_016077.3) Inquiry
SHH386928 shRNA set against Mouse PTRH2 (NM_175004.2) Inquiry
SHH386932 shRNA set against Rat PTRH2 (NM_001013860.1) Inquiry
SHR150844 shRNA set against Human PTRH2(NM_016077.3) Inquiry
SHR154254 shRNA set against Mouse Ptrh2(NM_175004.2) Inquiry
SHW002353 shRNA set against Chicken PTRH2 (NM_001040413) Inquiry
SHW008614 shRNA set against Danio rerio PTRH2 (NM_001020535) Inquiry
Cat.No. Product Name Price
CDCB186798 Rabbit PTRH2 ORF clone (XM_008271196.1) Inquiry
CDFG000111 Human PTRH2 cDNA Clone(NM_016077.3) Inquiry
CDFR002942 Rat Ptrh2 cDNA Clone(NM_001013860.1) Inquiry
MiUTR1H-08486 PTRH2 miRNA 3'UTR clone Inquiry
MiUTR1M-09786 PTRH2 miRNA 3'UTR clone Inquiry
MiUTR1R-06534 PTRH2 miRNA 3'UTR clone Inquiry
SKO0984 PTRH2 Validated sgRNA vector Inquiry
CDCB159607 Human PTRH2 ORF clone (BC006807) Inquiry
CDCB163828 Chicken PTRH2 ORF Clone (NM_001040413) Inquiry
CDCB170089 Danio rerio PTRH2 ORF Clone (NM_001020535) Inquiry
CDCH070040 Mouse Ptrh2 ORF clone (NM_175004.2) Inquiry
CDCR235587 Mouse Ptrh2 ORF Clone(NM_001098810.2) Inquiry
CDCR300485 Human PTRH2 ORF Clone(NM_016077.3) Inquiry
CDCR370028 Rat Ptrh2 ORF Clone(NM_001013860.1) Inquiry
CDCS414160 Human PTRH2 ORF Clone (BC006807) Inquiry
Quick Inquiry