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prps1a


Official Full Name
phosphoribosyl pyrophosphate synthetase 1A
Organism
Danio rerio
Gene ID
140620
Background
Predicted to enable ribose phosphate diphosphokinase activity. Involved in actin filament bundle organization. Acts upstream of or within inner ear development. Predicted to be part of ribose phosphate diphosphokinase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alar plate midbrain region; caudal hematopoietic tissue; immature eye; nervous system; and yolk. Used to study Charcot-Marie-Tooth disease X-linked recessive 5 and X-linked deafness 1. Human ortholog(s) of this gene implicated in Arts syndrome; X-linked deafness 1; X-linked recessive disease (multiple); gout; and retinitis pigmentosa. Orthologous to human PRPS1 (phosphoribosyl pyrophosphate synthetase 1). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
cb96; prps1; zgc:55299; zgc:76932; wu:fa18f03; wu:fb33h12; wu:fd26g08

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