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PDP1


Official Full Name
pyruvate dehydrogenase phosphatase catalytic subunit 1
Organism
Homo sapiens
Gene ID
54704
Background
Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]
Synonyms
PDH; PDP; PDPC; PPM2A; PPM2C; PDPC 1

Cat.No. Product Name Price
SHH372980 shRNA set against Human PDP1 (NM_018444.3) Inquiry
SHH372984 shRNA set against Mouse PDP1 (NM_001033453.3) Inquiry
SHH372988 shRNA set against Rat PDP1 (NM_019372.4) Inquiry
SHR067542 shRNA set against Rat Olr769_predicted(NM_001000371.1) Inquiry
SHR132666 shRNA set against Mouse Ppm2c(NM_001033453.3) Inquiry
SHW003425 shRNA set against Chicken PDP1 (NM_001199910) Inquiry
SHW012114 shRNA set against Danio rerio PDP1 (NM_001111158) Inquiry
Cat.No. Product Name Price
MiUTR4H-TG06578 PDP1 miRNA 3'UTR clone Inquiry
CDFH014014 Human PDP1 cDNA Clone(NM_001161781.1) Inquiry
CDFH014013 Human PDP1 cDNA Clone(NM_001161780.1) Inquiry
CDFH014012 Human PDP1 cDNA Clone(NM_001161779.1) Inquiry
CDCL147771 Mouse Pdp1 ORF clone (NM_001098230.1) Inquiry
MiUTR1M-09481 PDP1 miRNA 3'UTR clone Inquiry
CDCS419213 Human PDP1 ORF Clone (BC047619) Inquiry
CDCR378657 Rat Pdp1 ORF Clone(NM_019372.4) Inquiry
CDCR354168 Human PDP1 ORF Clone(NM_001161781.1) Inquiry
CDCL147773 Human Pdp1 ORF clone (NM_001098231.1) Inquiry
CDCL147769 Mouse Pdp1 ORF clone (NM_001033453.3) Inquiry
CDCL147767 Human PDP1 ORF clone (NM_001161779.1) Inquiry
CDCH018671 Human PDP1 ORF clone(NM_018444.3) Inquiry
CDCB195337 Rabbit ORYCUNV1R1541 ORF clone (NM_001167230.1) Inquiry
CDCB184410 Rabbit PDP1 ORF clone (XM_008255734.1) Inquiry
CDCB173589 Danio rerio PDP1 ORF Clone (NM_001111158) Inquiry
CDCR354165 Human PDP1 ORF Clone(NM_001161780.1) Inquiry
CDCB164900 Chicken PDP1 ORF Clone (NM_001199910) Inquiry
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