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PICALM


Official Full Name
phosphatidylinositol binding clathrin assembly protein
Organism
Homo sapiens
Gene ID
8301
Background
This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Synonyms
LAP; CALM; CLTH

Cat.No. Product Name Price
SHH375300 shRNA set against Human PICALM (NM_007166.3) Inquiry
SHH375304 shRNA set against Mouse PICALM (NM_146194.4) Inquiry
SHH375308 shRNA set against Rat PICALM (NM_053554.2) Inquiry
Cat.No. Product Name Price
CDCL149131 Human PICALM ORF clone (NM_001206946.1) Inquiry
MiUTR3H-05568 PICALM miRNA 3'UTR clone Inquiry
MiUTR3H-05569 PICALM miRNA 3'UTR clone Inquiry
CDCB194393 Rabbit PICALM ORF clone (XM_008263075.1) Inquiry
CDCL149133 Human PICALM ORF clone (NM_001206947.1) Inquiry
CDCR268150 Mouse Picalm ORF Clone(NM_146194.4) Inquiry
CDCR380355 Rat Picalm ORF Clone(NM_053554.2) Inquiry
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