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otofa


Official Full Name
otoferlin a
Organism
Danio rerio
Gene ID
557476
Background
Predicted to enable AP-2 adaptor complex binding activity and calcium ion binding activity. Acts upstream of or within several processes, including response to auditory stimulus; sensory perception of sound; and startle response. Predicted to be located in several cellular components, including Golgi membrane; basolateral plasma membrane; and endoplasmic reticulum membrane. Predicted to be active in presynaptic active zone membrane and synaptic vesicle membrane. Is expressed in nervous system; otic vesicle; and trigeminal placode. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 9. Orthologous to human OTOF (otoferlin). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
otof; fj34b10; wu:fj34b10; si:dkey-181f18.3

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