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Oas1b


Official Full Name
2'-5' oligoadenylate synthetase 1B
Organism
Mus musculus
Gene ID
23961
Background
This gene is a member of the 2'-5' oligoA synthetase family, which are clustered on chromosome 5. The encoded protein functions in the interferon-regulated OAS/RNase L system, which mediates RNA decay as part of the innate antiviral immunity pathway. The protein binds double-stranded RNA and oligomerizes ATP, which activate the single-stranded RNA cleavage enzyme RNase L. This protein mediates resistance to flaviviruses such as West Nile virus. The majority of wild mouse strains produce a functional protein and are resistant to flavivirus infection, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a premature stop codon that inactivates this gene product. [provided by RefSeq, Jul 2008]
Synonyms
Oas1b; L1; Flv; Wnv; Oas1; Oias2; Mmu-L1; Oias-2

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SHH356924 shRNA set against Rat Oas1b (NM_144752.2) Inquiry
SHH356956 shRNA set against Mouse Oas1g (NM_011852.2) Inquiry
SHR028552 shRNA set against Mouse Oas1b(NM_001083925.1) Inquiry
SHR028848 shRNA set against Rat Oas1b(NM_144752.2) Inquiry
Cat.No. Product Name Price
CDCL140981 Mouse Oas1b ORF clone (NM_001083925.1) Inquiry
CDFR014456 Rat Oas1b cDNA Clone(NM_144752.2) Inquiry
MiUTR1M-07926 OAS1B miRNA 3'UTR clone Inquiry
MiUTR1M-07928 OAS1G miRNA 3'UTR clone Inquiry
MiUTR1R-04342 OAS1B miRNA 3'UTR clone Inquiry
CDCL140997 Human Oas1g ORF clone (NM_011852.2) Inquiry
CDCR381503 Rat Oas1b ORF Clone(NM_144752.2) Inquiry
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