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notch1a


Official Full Name
notch receptor 1a
Organism
Danio rerio
Gene ID
30718
Background
Predicted to enable Notch binding activity. Involved in Notch signaling pathway and hematopoietic stem cell differentiation. Acts upstream of or within with a positive effect on regulation of non-canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including cell differentiation in spinal cord; chordate embryonic development; and regulation of cell fate specification. Is active in plasma membrane. Is expressed in several structures, including digestive system; fin; mesoderm; nervous system; and tail bud. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia/lymphoma; aortic valve disease 1; and congenital heart disease. Orthologous to human NOTCH1 (notch receptor 1). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
des; n1a; wu:fc01e02; wu:fc37a05

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