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mthfd1b


Official Full Name
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b
Organism
Danio rerio
Gene ID
260441
Background
Predicted to enable methenyltetrahydrofolate cyclohydrolase activity and methylenetetrahydrofolate dehydrogenase (NADP+) activity. Predicted to be involved in tetrahydrofolate interconversion. Predicted to act upstream of or within one-carbon metabolic process. Predicted to be active in cytosol. Is expressed in several structures, including anterior neural tube; digestive system; immature eye; nervous system; and optic primordium. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; abdominal aortic aneurysm; cleft lip; developmental cardiac valvular defect; and neural tube defect (multiple). Orthologous to human MTHFD1 (methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
cb325; mthfd1; fc29f07; zgc:55597; wu:fc29f07

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